2025

                                      Professor Lubell presented at the 2025 Pacifichem in Honolulu, Hawaii !​​

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1. Our recent work on solvent-less peptide synthesis was spotlighted by the American Peptide Society! See: https://americanpeptidesociety.org/aps-news/acoustic-coupling/

2. Publications…​

   • ...Solvent-less environmentally benign amino ester, amide, and peptide synthesis enabled by resonant acoustic mixing: RSC Green Chemistry (DOI: 10.1039/D5GC04619J)

   • … on IL-6R modulation to prevent inflammation-induced preterm birth : EMBO Molecular Medicine (DOI: 10.1038/s44321-025-00257-9).

   • …on “Selective Azapeptide CD36 Ligand MPE-298 Regulates oxLDL-LOX-1-Mediated Inflammation and Mitochondrial Oxidative Stress in Macrophages” : Cells (DOI: 10.3390/cells14050385).

   • …on “Inhibition of Interleukin-1 Signaling Protects Against Group B Streptococcus-Induced Preterm Birth and Fetal Loss in Mice”: Journal of Reproductive Immunology (DOI: 10.1016/j.jri.2025.104520).

   • …Aza-Isotryptophan: Synthesis, Pictet–Spengler Chemistry, Incorporation and Conformational Analysis in Peptides, and Activity in Modulators of the Cluster of Differentiation-36 Receptor : Journal of Medicinal Chemistry (DOI: 10.1021/acs.jmedchem.5c01693)

   • ...alkoxy-Substituted Anisomycins as Potent Anti-Trypanosomiasis Activity and Expanded Modes of Action: Journal of Medicinal Chemistry (DOI: 10.1021/acs.jmedchem.5c01291).

3. Conferences…

   • Charity, Yousra and Bill attended the 2025 International Chemical Congress of Pacific Basin Societies held  15-20 December 2025 in Honolulu, Hawaii.  With Professors Caroline Proulx (NCSU), Hiroaki Suga (U. Tokyo), and John Wade (Florey Instute), Bill organized a two day symposium: Aardvarks to Zebus, Challenging Chemistry Targets and Innovative Solutions in Synthetic, Medicinal and Biological Peptide and Protein Science.  Charity spoke on "Synthetic methods towards β-amino and β-hydroxy γ-lactam peptidomimetics”.  Bill gave a talk on "Peptide mimicry with semicarbazides as amino amide surrogates towards treating unmet medical conditions”.  In addition,  Yousra presented a poster with Felix and Bill as co-authors entitled “One-step synthesis of hydroxyurea amino acid derivatives using resonant acoustic mixing in ethanol” in the session: Green Techniques For Organic & Medicinal Chemistry.

   • Kajumee and Kinshuk attended the 2025 Quebec/Ontario Mini-Symposium for Synthetic and Bioorganic Chemistry (QOMSBOC) held at 14-16th November, Université Laval in Quebec city, Canada. Kajumee and Kinshuk gave a talk on "Bending Peptides with Novel Cyrene-Derived a,a-Disubstituted Amino Acids’” and "peptide synthesis using Resonant Acoustic Mixing" respectively.​

4. Editorials…

   • …on the challenges of clarifying peptide synthesis nomenclature : Journal of Peptide Science (DOI: 10.1002/psc.70043).

   • …on the potential of mining nature for G protein coupled receptor-based drug discovery : British Journal of Pharmacology (DOI: 10.1111/bph.70072).

5. Mini Review… on “N-to-C Peptide Synthesis, Arguably the Future for Sustainable Production”: Journal of Peptide Science (DOI: 10.1002/psc.70019).

6. Review… on “Recent Advances in Sustainable Total Synthesis and Chiral Pool Strategies with Emphasis on (−)‐Sclareol in Natural Products Synthesis” : European Journal of Organic Chemistry (DOI: 10.1002/ejoc.202400983)

7. New Postdoctoral Fellow… Michael received a distinguished PBEEE/Quebec Merit Scholarship for Foreign Postdocs and Visiting Research Student and Visiting Researchers

8. New Undergraduate Fellows… Arnaud and Rita received NSERC – Undergraduate Student Research Awards and Amir received the Centre in Green Chemistry and Catalysis Fellowship

9. Doctoral scholar … Nassim received a FRQNT doctoral training scholarship

10. Best Oral Presentation … Congratulations to Darince on his talk “Nitrogen Chirality” at the 2025 Canadian Society of Chemistry Meeting in Ottawa!

11. Conference presentations… Darince (oral) and Yousra, Charity, and Kajumee (posters) will present at the 2025 Canadian Society of Chemistry Meeting in Ottawa. Chitra and Ida (poster) will present at the 2025 American Peptide Society Meeting in San Diego.

12. New cegep student… Laura comes onboard!

13. New Ph.D. student… Zahra comes onboard!

14. The Molecular Marvels of the Transformers" is most viewed content of  ChemistryViews’ in 2024 (https://www.chemistryviews.org/the-content-you-liked-best-in-2024/). 

15. ​Congratulations to Charity and Yousra on their a best posters at the 2nd Canadian Peptide and Protein Community virtual meeting, see https://sciforum.net/event/2ndCPPC#instructions?section=#sessions

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